In the ever-evolving cyber landscape, nation-state actors pose a growing threat with their sophisticated Advanced Persistent Threats (APTs). These relentless attacks demand a robust cybersecurity program specifically designed to counter their cunning tactics. This talk delves into the critical components of such a program, outlining strategies for PRoactive Threat Intelligence, Multi-Layered Defense, User Vigilance Training, Continuous Monitoring and Incident Response, and Collaboration and Information Sharing.